Astragalus root (taken orally) has been reported to be effective against CKD (chronic kidney disease) based on several metabolic markers for kidney health, such as the estimated glomerular filtration rate (eGFR); serum creatinine, haemoglobin, and albumin levels. The kidneys filter waste products from the blood while retaining what the body needs — including proteins. However, some diseases and conditions that affect the kidney allow proteins to pass through the filters of the kidneys, causing protein to be present in the urine. Astragalus supplementation has also been shown to improve markers for proteinuria and albuminuria (proteins detected in the urine).

Beetroot is a source of several bioactive compounds, such as nitrate, betaine, and betalain, and has shown beneficial effects in CKD (chronic kidney disease) and general kidney health, including reduction of blood pressure, anti-inflammatory effects, and antioxidant actions by scavenging radical oxidative species. Beetroot consumption as a possible therapeutic strategy to improve the clinical treatment of patients with CKD or impaired kidney function have been observed in several preclinical studies.

Resveratrol is a plant-based polyphenol that is found in abundance in grapes and may protect kidneys from a variety of toxins—including heavy metals, steroids, drugs, and alcohol—that can cause renal injury. Not only does resveratrol act as antioxidant and anti-inflammatory compound to fortify your kidneys against injury it may also improve renal function once an injury or disease has occurred.

Cordyceps sinensis is a fungus that has been extensively studied as a potential therapeutic to confer a variety of beneficial effects on the body. Its extracts have effects of nephroprotection, hepatoprotection, neuroprotection, and protection against reperfusion-induced injury, as well as anti-inflammatory and antioxidant activities. Cordyceps preparations administered orally have been persistently found to significantly decrease serum creatinine; increase creatinine clearance and reduce 24 hour proteinuria (proteins detected in the urine).

An antioxidant synthesised inside the mitochondrion (the powerhouse inside every cell in your body) where it helps key enzymes turn nutrients into usable energy. ALA can protect cells from oxidative damage, including those in your kidneys, through the increased production of two other key antioxidants—superoxide dismutase (SOD) and catalase (CAT)—in kidney tissue. These enzymes catalyse reactions that assist in reducing inflammation and oxidative stress. ALA has also been shown to increase insulin sensitivity and help reduce blood sugar and lipids, largely through improving measures of oxidative stress and inflammation.

The hawthorne plant, its berries, leaves, and flowers are all extensively used in a variety of herbal medicines that have a variety of effects. In some studies, hawthorne has been shown to act as a vasodilator (widening the blood vessels) and thereby increases the amount of blood pumped out of the heart, meaning it can relax constricted blood vessels, ultimately lowering blood pressure. Hawthorne berries in particular are a rich source of polyphenols which are powerful antioxidant compounds found in plants. Animal-based studies have shown that hawthorn berry extract significantly decreased levels of inflammatory compounds, leading to reduced inflammation and injury, in both the liver and kidneys.

Pine bark extract offers a natural solution for individuals suffering from various metabolic syndromes, particularly for kidney protection. Studies have shown pine bark as a supplement to anti-hypertensive medication further improves kidney flow and kidney function. Pine bark has also been shown in several studies to lower blood glucose in diabetic patients and can also be useful in the prevention and treatment of kidney stones due to the high diuretic properties and antioxidant activity.

BioPerine® is a patented extract obtained from black pepper fruits (Piper nigrum) and may be co-administered with various nutrients to enhance their bioavailability. The addition of small amounts of BioPerine® to nutraceutical supplements has been found to enhance absorption of nutrients by at least 30%.

Microcrystalline cellulose and Perkasil are refined wood pulp and precipitated amorphous silica respectively. These agents are used as texturizers and anti-caking agents, most commonly used in vitamin supplements or tablets. These agents are considered industry standard, vegan-friendly substrates to ensure proper encapsulation and longevity of the vegetable capsules, containing Solace's Kidney+ ingredients.